1.
Cannabinoid receptors: Targets for endogenous and exogenous ligands
| Symposium Sponsored by: |
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B. Szabo (Freiburg,
Germany) Organizer | szabo@pharmakol.uni-freiburg.de
Institut für Experimentelle und Klinische Pharmakologie und Toxikologie,
Albert-Ludwigs-Universität, Freiburg i. Br., Germany
V. Di Marzo (Napoli, Italy) Organizer | vdimarzo@icmib.na.cnr.it
Istituto di Chimica Biomolecolare Consiglio Nazionale delle Ricerche, Comprensorio
Olivetti 80078 Pozzuoli (NA), Italy
Regulation of endocannabinoid biosynthesis
V. Di Marzo (Napoli, Italy) | vdimarzo@icmib.na.cnr.it
Modulation of synaptic transmission by exogenous and endogenous cannabinoids
B. Szabo (Freiburg, Germany) | szabo@pharmakol.uni-freiburg.de
Analgesic effects of cannabinoid receptor agonists
Victoria Chapman (Nottingham, UK) | Victoria.Chapman@nottingham.ac.uk
Cannabinoid receptors and reward mechanisms
Liana Fattore (Cagliari, Italy) | fattore@ca.cnr.it
Role of endocannabinoids in the regulation of behaviour
Andreas Zimmer (Bonn, Germany) | a.zimmer@uni-bonn.de
Pharmacology of cannabinoid receptor antagonists - possible therapeutic
applications
Gerard Le Fur (Paris, France) | gerard.le-fur@sanofi-synthelabo.com |
2. Nitric oxide and
airway function
F.P. Nijkamp (The
Netherlands) Organizer | F.P.Nijkamp@pharm.uu.nl
Faculty of Pharmacy, Dept. Pharmacology and Pathophysiology, Sorbonnelaan 16, 3584 CA
Utrecht, The Netherlands
J. Zaagsma (The Netherlands) Organizer | j.zaagsma@farm.rug.nl
Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands
Reactive oxygen -and nitrogen species in asthma and COPD
G. Folkerts (The Netherlands)
Utrecht University, Utrecht, The Netherlands.
Protective effect of nitric oxide in (human) airways
F.L. Ricciardolo (Italy)
G Gaslini Institute, Genoa, Italy.
Arginine homeostasis in healthy and asthmatic airways
H. Meurs (The Netherlands)
University of Groningen, Groningen, The Netherlands.
Differential control of iNOS and arginase in airway cells
K. Racké (Germany)
University of Bonn, Bonn, Germany.
Arginase inhibitors and alternative substrates of nitric oxide synthases.
J.L. Boucher (France)
University of Paris V, Paris, France. |
3.
Inhibition of apoptotic pathways in neurodegenerative diseases and stroke
K. Fink Organizer
| finkk@uni-bonn.de
Dept. Neuropharmacology, Univ. Clinic Bonn, Reuterstr. 2b, 53113 Bonn, Germany
E. Clementi Organizer | clementi.emilio@hsr.it
Dept. of Pharmacology, University of Calabria, Rende, and Cellular Pharmacology Unit, H
San Raffaele Scientific Institute, Milan, Italy
Caspase inhibitors and statins improve outcome in murine models of stroke and
neurodegeneration
K. Fink (Bonn, Germay) | finkk@uni-bonn.de
Protective effect of a caspase inhibitor in cerebral ischemia
C. Wiessner (Basle, Switzerland) | Christoph.wiessner@pharma.novartis.com
Novartis Pharma AG, Nervous System Research/Neurodegeneration, CH-4002 Basle, Switzerland
NO as an upstream inhibitor of programmed cell death
E. Clementi (Milan, Italy) | clementi.emilio@hsr.it
Role of apoptosis and identification of
biomarkers in Alzheimer's disease
M. Ankarcrona (Sweden) | maria.ankarcrona@neurotec.ki.se
The Alzheimer Disease Research Center, Karolinska Institute, Neurotec Division of
Geriatric Medicine, Huddinge University Hospital, S-14186 Stockholm, Sweden |
4. Inflammation and vascular disease
5. ß3-Adrenoceptors
and atypical ß-adrenoceptors - an update
E. Schlicker (Bonn, Germany) Organizer
| e.schlicker@uni-bonn.de
Department of Pharmacology and Toxicology, University of Bonn, Bonn, Germany
J.R.S. Arch (Buckingham, UK) Organizer | jon.arch@buckingham.ac.uk
Clore Laboratory, University of Buckingham, Buckingham, UK
Pharmacological analysis of cardiac and adipose tissue ß3-adrenoceptors
with transgenic models
G. Tavernier (Toulouse, France)
ß3-Adrenoceptor agonists in obesity and type 2 diabetes: humans versus rodents
J.R.S. Arch (Buckingham, UK)
ß3-Adrenoceptor agonists in urinary bladder function
M.C. Michel (Amsterdam, The Netherlands)
The low-affinity state of the ß1-adrenoceptor in the heart
A.J. Kaumann (Cambridge, UK)
Vasorelaxant atypical ß-adrenoceptors: Are they different from the cardiac low-affinity
state of the ß1-adrenoceptor?
B. Malinowska (Bialystok, Poland) |
6.
Cross-talk of the neuronal and immune assistance in pain and inflammation
K. Brune Organizer
| brune@pharmakologie.uni-erlangen.de
Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
Opioids from invading leukocytes modulate infalmmatory pain
M. Schäfer (Berlin, Germany)
Neuroimmunology and pain: Effects of cytokines on nociceptor activity
M. Kress (Innsbruck, A)
Immunpharmacological modulation of glycinergic transmission in nociception
U. Zeilhofer (Erlangen, Germany)
NGF and BDNF: Modulation of nociception
S.B. McMahon (London, U.K.) |
7. Innovation in
pharmacology teaching and learning
Dewhurst Organizer
| d.dewhurst@ed.ac.uk
College of Medicine & Veterinary Medicine, The University of Edinburgh, Edinburgh,
U.K.
D. Moura (Porto, Portugal) Organizer | dmoura@med.up.pt
Institute of Pharmacology and Therapeutics Faculty of Medicine, University of Porto
Opportunities for the expansion of pharmacology teaching and training
programmes in Europe
D. Moura (Portugal)
Resource discovery and support networks for pharmacology teachers
I. Hughes (Leeds, U.K.)
Re-usable Learning Objects and Virtual Learning Environments - managing and
delivering e-learning resources
D. Dewhurst (Edinburgh, U.K.)
Teaching Pharmacology in Brazil
R. Soares de Moura (Rio de Janeiro, Brazil) |
8. ATP-sensitive K channel openers
9. Endothelial cell dysfunction and
pulmonary hypertension
U. Simonsen Organizer
Department of Pharmacology, University of Aarhus, Denmark
R. M. Wadsworth Organizer
Department of Physiology and Pharmacology, Strathclyde University, Scotland
Pathophysiology of endothelium in pulmonary hypertension
Rubin Tuder (Baltimore, USA)
Nitric oxide donors and pulmonary hypertension
Britt Elmedal (Aarhus, Denmark)
Superoxide mimetics and pulmonary hypertension
Roger Wadsworth (Glasgow, Scotland)
Endothelin receptor antagonists and pulmonary
hypertension
Ulf Simonsen (Aarhus, Denmark)
Angiogenic factors and pulmonary hypertension
Serge Adnot (Creteil, France) |
10. Optical
studies of receptor activation in neural structures
B. Lendvai
Organizer
Department of Pharmacology, Institute of Experimental Medicine, Budapest, Hungary
Modulation of dendritic calcium dynamics by nicotinic receptors.
Balazs Lendvai
Optical quantal analysis of plasticity at glutamatergic synapses in the
hippocampus.
Alan Fine
Pharmacological control of synapse formation in hippocampal organotypic slice
cultures
Dominique Muller
Control of dendritic excitability and transmitter release by dopamine and calcium
activated ion channels in olfactory bulb
Kerry Delaney |
11. Amphetamines: from
pharmacology to toxicology
R. Corradetti
Organizer | corradet@pharm.unifi.it
Department of Preclinical and Clinical Pharmacology, University of Florence, Florence,
Italy
F.D. Carvalho Organizer | felixdc@ff.up.pt
Laboratorio de Toxicologia, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal
Acute pharmacological effects of MDMA in rodents. Report by the EC Ecstasy-damage
Group: neurochemical and electrophysiological findings
Renato Corradetti (Italy) | corradet@pharm.unifi.it
Acute and long-term pharmacological effects of MDMA in rats . Report by the EC
Ecstasy-damage Group: effects on behaviour, sleep and brain metabolism
Gyorgy Bagdy (Hungary) | bag13638@mail.iif.hu
The toxicity of amphetamines
Félix Carvalho (Portugal) | felixdc@ff.up.pt
Targets for MDMA neurotoxicity
M. Isabel Colado (Spain) | colado@med.ucm.es |
12.
Airway inflammation
N. Frossard (Organizer)
Chairpersons:
C. ADVENIER
University Paris V, France
P. GEPPETTI
University of Florence, Italy
Sensory nerves as a target for therapeutic intervention in airway
inflammatory diseases
M. BELVISI (U.K.)
National Heart and Lung Institute, London, UK.
Regulatory T-cells in asthma and immunotherapy
A. Van OOSTERHOUT (The Netherlands)
Utrecht University, The Netherlands
New pharmacological strategies for the therapy of allergic inflammatory response
P. M. R. SILVA (Brazil)
Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, BrazilPDE4 inhibitors and MUC5AC mucin secretion in human airway
epithelial cells
E. MORCILLO (Spain)
University of Valencia, Spain
Role of matrix metalloproteases in airway
inflammation
V. LAGENTE (France)
University of Rennes, France
Regulation of the expression of the mast cell growth factor SCF in
inflammatory and anti-inflammatory conditions
C. DA SILVA
Strasbourg, France and Yale University, USA |
13.
Allosteric modulators of G-protein coupled receptors as drugs
N.G.Bowery (UK) Organizer
| n.g.bowery@bham.ac.uk
Department of Pharmacology University of Birmingham Medical School Edgbaston B15 2TT UK
Allosteric enhancers and
activation of muscarinic receptors and other GPCRs
N. Birdsall (UK) | nbirdsa@nimr.mrc.ac.uk
Division of Physical Biochemistry National Institute for Medical Research Mill Hill,
London NW7 1AA, U.K.
Allosteric modulation of Group III metabotropic glutamate receptors in the
treatment of CNS disorders
T.Ramirez (Denmark) | TERA@Lundbeck.com
H. Lundbeck A/S Ottliavej 9 DK-2500 Valby
Positive allosteric modulation of g-aminobutyric acidB receptors
S. Urwyler (Switzerland) | stephan.urwyler@pharma.novartis.com
Novartis Pharma AG, TA Nervous System, CH-4002 Basel, Switzerland
Allosteric modulation of adenosine receptors
M. Beukers (The Netherlands) | beukers@chem.leidenuniv.nl
Division of Medicinal Chemistry Leiden/Amsterdam Center for Drug Research Gorlaeus
Laboratories. Einsteinweg 55 P.O. Box 9502 2300 RA Leiden
Discovery and development of calcimimetic compounds: Concept validation of
allosteric modulatory mechanisms for drugs targeting G protein-coupled receptors
L. Hammerland (USA) | lhammerland@npsp.com
NPS Pharmaceuticals 420 Chipeta Way Salt Lake City Utah 84108 USA |
14.
Function of pre- and postsynaptic P2 receptors in the normal and pathological nervous
system
Peter Illes (Leipzig,
Germany) Organizer | illp@medizin.uni-leipzig.de
Rudolf-Boehm-Institut für Pharmakologie und Toxikologie Universität Leipzig
Härtelstraße 16/18, 04107 Leipzig Tel.: 0341/97 24 600/Fax: 0341/97 24 609
Beáta Sperlágh (Budapest, Hungary) Organizer | sperlagh@koki.hu
Institute of Experimental Medicine, Hungarian Academy of Sciences H-1083 Budapest Szigony
u. 43, Hungary Phone:+36-1-210-9970, Fax: +36-1-210-9423
Regulation of P2X receptor-function by ecto-protein kinase C
Peter Illes (Leipzig, Germany)
Release and modulatory effects of ATP in hippocampal synapses
Rodrigo A. Cunha (Coimbra, Portugal)Immuno-electron microscopic localisation of P2X receptors
Jim Deuchars (Leeds, UK)
P2 receptor-operated neurotransmitter release
under normal and pathological conditions
Beáta Sperlágh (Budapest, Hungary)
Regulation of presynaptic ionotropic nucleotide
receptors
Maria Teresa Miras-Portugal (Madrid, Spain) |
15. Pharmacological
treatment of male erectile dysfunction
| Symposium Sponsored by: |
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I. Saenz-de-Tejada (Madrid, Spain) Organizer
| isdtejada@terra.es
Fundación para la Investigatión y el Desarrollo em Andrologia Departamento de
Investigatión Hospital Ramon y Cajal Madrid / SPAIN
K. E. Andersson (Lund, Sweden) Organizer
| karl-erik.andersson@klinfarm.lu.se
University Hospital of Lund Department of Clinical Pharmacology S-221 85 Lund /
SWEDEN
Basic pharmacology of PDE5 inhibitors
I. Sáenz de Tejada (Spain)
Clinical experience with PDE5 inhibitors in the
treatment of erectile dysfunction
Dimitri Hatzichristou (Greece)
Drugs and targets in the CNS for the treatment of
erectile dysfunction
Francois Giuliano (France)
New drugs and peripheral targets for the treatment
of erectile dysfunction: Rho kinase inhibitors, guanylyl cyclase activators
Karl-Erik Andersson (Sweden)
Mecanisms for drug induced erectile dysfunction
Javier Angulo (Spain) |
16.
Pharmacogenetics of transporters, receptors an enzymes
G. Suarez-Kurtz (Brazil) Organizer
Instituto Nacional de Câncer, Brazil
H. Kroemer (Germany) Organizer
University of Greifswald, Germany
Genomics of drug transporters
H. Kroemer (Germany)
University of Greifswald, Germany
Pyrimidine degradation defects and severe 5-fluorouracil toxicity
A. van Kuilenburg (Netherlands)
University of Amsterdam, Netherlands
Pharmacogenetic studies in admixed populations: The Brazilian case
G. Suarez-Kurtz (Brazil)
Instituto Nacional de Câncer, Brazil
Pharmacogenomics in the treatment of cardiovascular diseases
I. Cascorbi (Germany)
University of Greifswald, Germany |
18. P1
purinoceptors: Therapeutic implications for CNS disorders
J. Alexandre Ribeiro
(Portugal) Organizer | jaribeiro@neurociencias.pt
Laboratory of Neurosciences, Faculty of Medicine, University of Lisboa, Av. Prof Egas
Moniz, 1649-028 Lisboa, Portugal
ADENOSINE RECEPTORS:PATHOPHYSIOLOGICAL IMPLICATIONS
J.Alexandre Ribeiro (Lisbon, Portugal)
DOPAMINE AND ADENOSINE RECEPTORS AS BASIS FOR THE TREATMENT OF PARKINSON'S DISEASE
Micaela Morelli (Cagliari, Italy)
INTERACTIONS BETWEEN A2A AND GLUTAMATE mGlu5 RECEPTORS IN THE STRIATUM.
IMPLICATIONS FOR NEUROPSYCHIATRIC DISORDERS AND DRUG ABUSE
Kjell Fuxe (Stockholm, Sweden)
INTERACTIONS BETWEEN OPIOID RECEPTORS AND THE ADENOSINE SYSTEM
Susanna Hourani (Surrey, UK) |
19. Regulation of electrolyte and amino-acid
transporters
P. Soares da Silva (Portugal)
Organizer| psoaresdasilva@netcabo.pt
Instituto de Farmacologia e Terapêutica, Faculdade de Medicina, Universidade do
Porto
A.W. Cuthbert (Cambridge, U.K.) Organizer | awc1000@cam.ac.uk
Department of Medicine, University of Cambridge
Transepithelial amino acids transport
F. Verrey (Zurich, Switzerland) | verrey@access.unizh.ch
Institute of Physiology, University of Zurich
The pharmacology of CFTR
A.W. Cuthbert (Cambridge, U.K.) | awc1000@cam.ac.uk
Department of Medicine, University of Cambridge
WNK kinases and distal sodium reabsorption
J. Achard (Limoges, France) | jean-michel.achard@unilim.fr
Department of Physiology, University of LimogesInfluence of Na+/H+-exchanger-3 on receptor-mediated
endocytosis
M. Gekle (Wurzburg, Germany) | michael.gekle@mail.uni-wuerzburg.de
Physiologisches Institut, Universitat Wurzburg
Regulation of sodium and potassium transepithelial
flux
P. Soares-da-Silva (Porto, Portugal) | psoaresdasilva@netcabo.pt
Instituto de Farmacologia e Terapêutica, Faculdade de Medicina, Universidade do
Porto |
20. Modulation of neuronal
exocytosis
K. Starke (Germany) Organizer|
Klaus.Starke@pharmakol.uni-freiburg.de
Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Otto
Krayer Haus, Freiburg
S. Guimarães (Portugal) Organizer| sguimara@med.up.pt
Instituto de Farmacologia e Terapêutica, Faculdade de Medicina, Universidade do
Porto
How Clostridium sordelli lethal toxin blocks neurotransmitter exocytosis
Y. Humeau, F. Doussau, B. Poulain (Strasbourg)
The inhibition of specific ion channels as basis for antipodal effects of
muscarinic receptor activation on sympathetic transmitter release
S. Böhm (Vienna)
Pharmacological characterization of prejunctional angiotensin II receptors
S. Guimarães, D. Moura (Porto)
Different AT1-receptor
subtypes at prejunctional and postjunctional sites
J.C. Balt, A. Nap., M. Mathy, P. van Zwieten (Amsterdam)
Alpha-2-adrenoceptor modulation of neuronal exocytosis: insights from
gene-targeted mice
L. Hein (Würzburg), A. Knaus, V. Muthig
Signalling transduction mechanisms of inhibitory P2Y-receptors located at
noradrenergic axon terminals
I. von Kügelgen (Bonn)
Interaction of facilitatory adenosine receptors and presynaptic-inhibitory
receptors on noradrenaline release
J. Gonçalves (Porto)
Adenosine A2A receptor-induced inhibition of NMDA and GABAA
receptor-mediated synaptic currents in a subpopulation of rat striatal neurons
W. Nörenberg (Leipzig)
Hippocampal presynaptic receptors and memory
R. Jackisch (Freiburg i.Br.), J. Cassel (Strasbourg) |
22. EDHF
P. M. Vanhoutte Organizer|
vanhoutte.hku@hku.hk
Department of Pharmacology, University of Hong Kong
Historical notes: the other EDRF
P. M. Vanhoutte | vanhoutte.hku@hku.hk
P-450 monooxygenases as EDHF-synthase(s)
I. Fleming (Germany)| Fleming@em.uni-frankfurt.de
Institut für Kardiovaskuläre Physiologie, Klinikum der JWG-Universität,
Frankfurt am Main, Germany
Potassium and the potassium cloud
A. Weston (UK) | aweston@man.ac.uk
School of Biological Sciences, University of Manchester, Manchester, UK
Gap junctions: the obligatory links
T. Griffith (UK) | griffith@cardiff.ac.uk
Department of Diagnostic Radiology, Wales Heart Research Institute, University of
Wales College of Medicine, UK
Actions of EDHF on vascular smooth muscle
M. Félétou (France) | michel.feletou@fr.netgrs.com
Département Diabète et Maladies Métaboliques, Institut de Recherches Servier,
Suresnes, France. |
23. Pain - new concepts
and strategies for control
G. Alexander Rae
(Brazil) Organizer | garae@pop.com.br
Department of Pharmacology, CCB, Universidade Federal de Santa Catarina, Brazil
S.H. Ferreira (Brazil) Chair | shferrei@fmrp.usp.br
Department of Pharmacology,Faculty of Medicine of Ribeirao Preto, University of Sao Paulo,
Brazil
Separate mechanisms for mechanical and thermal sensory transduction
C. Belmonte (Spain)
Importance of TTX-resistant sodium channel (Nav. 1.8) for inflammatory pain
transduction
J. N. Wood (U.K.)
Relative importance of nociceptor types (high threshold) and silent nociceptors in
thermal and mechanical inflammatory hypernociception (allodynia/ hyperalgesia)
H.O. Handwerker, (Germany)
Chronic pain and persistent inflammatory hypernociception
S.H. Ferreira (Brazil) |
24.
Constitutive activity of G-protein coupled serotonergic receptor subtypes: moving toward
its functional significance within the CNS
Umberto
Spampinato (France) Organizer | umberto.spampinato@lnpb.u-bordeaux2.fr
Bordeaux 2 University, Neuropsychobiologie Des
Desadap, UMR CNRS 5541, 146 Rue Leo Saigmat, BP 31 Bordeaux, 33076 France
William P. Clarke (USA) Organizer | clarkew@uthscsa.edu
Health Science Center, University of Texas, San Antonio, USA
Constitutive activity and pleiotropic behavior of the human 5-HT2C receptor in
heterologous expression system
William P Clarke (USA) | clarkew@uthscsa.edu
Pharmacological and
structural evidence for silent, inactive and constitutively active 5-HT4 receptors
Joel Bockaert (France) | joel.bockaert@ccipe.cnrs.fr
Evidence that constitutive
activity of the serotonin 5-HT2A receptor regulates learning
John Harvey (USA) | john.harvey@drexel.edu
Constitutive activity of the serotonin 2C receptor plays a prominent role in
regulating mesencephalic dopaminergic neuron activity in vivo
P. De Deurwaerdére (France) | deurwaer@lnpb.u-bordeaux2.fr |
25. 5-HT receptors in
gastro-intestinal disorders
Daniel Hoyer (Switzerland)
Organizer | daniel1.hoyer@pharma.novartis.com
Preclinical Research 386/525 Novartis Pharma Ltd CH-4002 Basel Switzerland
Distribution of 5-HT receptors in the gut and the peripheral nervous system
Daniel Hoyer (Switzerland)
5-HT modulation in preclinical models of irritable bowel syndrome
V. Martinez
5-HT modulation in preclinical models of reflux and transit
(speaker to be confirmed)
Clinical applications in irritable bowel syndrome and other gastrointestinal disorders
H.J. Pfannkuche (Switzerland) |
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